A dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22

LT175 – 10 mg

Brand:
Cayman
CAS:
862901-87-9
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively).{28659} It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice.{28659} LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPARγ.{28659}  

 

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Description

A dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively); improves glucose homeostasis in diet-induced insulin resistant mice

Formal name: αS-([1,1′-biphenyl]-4-yloxy)-benzenepropanoic acid

Synonyms: 

Molecular weight: 318.4

CAS: 862901-87-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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