A brain penetrant positive allosteric modulator of the mGluR5 (EC50 = 24 nM); reverses learning deficits in a rat model of schizophrenia

LSN2463359 – 10 mg

Brand:
Cayman
CAS:
1401031-52-4
Storage:
-20
UN-No:
Non-Hazardous - /

LSN2463359 is a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5; EC50 = 24 nM).{34519} It is without effect at other mGluRs. LSN2463359 is brain penetrant and reverses learning deficits in a rat model of schizophrenia.{34519,34521} Through its effects on mGluR5, LSN2463359 attenuates deficits in performance in operant behavior induced by SDZ-220581, an NMDA (Item No. 14581) receptor antagonist, in rats.{34520,34521} It also promotes wakefulness in animals.{34521}  

 

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Description

A brain penetrant positive allosteric modulator of the mGluR5 (EC50 = 24 nM); reverses learning deficits in a rat model of schizophrenia

Formal name: N-(1-methylethyl)-5-[2-(4-pyridinyl)ethynyl]-2-pyridinecarboxamide

Synonyms: 

Molecular weight: 265.3

CAS: 1401031-52-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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