A potent

LRRK2-IN-1 – 1 mg

Brand:
Cayman
CAS:
1234480-84-2
Storage:
-20
UN-No:
Non-Hazardous - /

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson’s disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. LRRK2-IN-1 is a potent inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively).{29460} It is selective for LRRK2 over a large panel of other kinases. LRRK2-IN-1 treatment causes dephosphorylation of LRRK2, leading to its dissociation from 14-3-3 proteins, ubiquitination, and degradation.{29460,29462} Inhibitors of LRRK2, including LRRK2-IN-1, stimulate macroautophagy in H4 neuroglioma cells.{29461}  

 

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Description

A potent, selective inhibitor of LRRK2 that inhibits both wild-type and G2019S mutant LRRK2 (IC50s = 13 and 6 nM, respectively); stimulates macroautophagy in H4 neuroglioma cells

Formal name: 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)- 1-piperidinyl]carbonyl] phenyl]amino]- 5,11-dimethyl-6H-pyrimido[4,5-b][1,4] benzodiazepin-6-one

Synonyms:  Leucine-rich repeat kinase 2 IN-1

Molecular weight: 570.7

CAS: 1234480-84-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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