An LPA2 antagonist (IC50 = 17 nM); selective for LPA2 over LPA1 and LPA3 (IC50s = >50 μM); inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells

LPA2 Antagonist 1 – 5 mg

Brand:
Cayman
CAS:
1017606-66-4
Storage:
-20
UN-No:
Non-Hazardous - /

LPA2 antagonist 1 is an antagonist of lysophosphatidic acid receptor 2 (LPA2; IC50 = 17 nM).{43178} It is selective for LPA2 over LPA1 and LPA3 (IC50s = >50 μM). LPA2 antagonist 1 inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells in a concentration-dependent manner.  

 

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Description

An LPA2 antagonist (IC50 = 17 nM); selective for LPA2 over LPA1 and LPA3 (IC50s = >50 μM); inhibits HGF-induced phosphorylation of ERK and proliferation of HCT116 colon cancer cells

Formal name: N-[(1S)-2-[4-[(3,4-dichlorophenyl)sulfonyl]-1-piperazinyl]-1-methylethyl]-7-methyl-thieno[3,2-d]pyrimidin-4-amine

Synonyms:  LPA2-IN-1

Molecular weight: 500.5

CAS: 1017606-66-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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