An agonist of 5-HT7 receptors (Ki = 0.58 nM); selective for 5-HT7 over 5-HT1A and dopamine D2 receptors (Kis = 188 and 142 nM

LP-211 – 10 mg

Brand:
Cayman
CAS:
1052147-86-0
Storage:
-20
UN-No:
Non-Hazardous - /

LP-211 is an agonist of the serotonin (5-HT) receptor subtype 5-HT7 (Ki = 0.58 nM).{48788} It is selective for 5-HT7 over 5-HT1A and dopamine D2 receptors (Kis = 188 and 142 nM, respectively). It induces relaxation of isolated guinea pig ileum precontracted by substance P (Item No. 24035; EC50 = 0.6 μM). LP-211 (100 nM) stimulates neurite outgrowth in primary murine striatal and cortical neurons.{48789}  

 

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SKU: 29659 - 10 mg Category:

Description

An agonist of 5-HT7 receptors (Ki = 0.58 nM); selective for 5-HT7 over 5-HT1A and dopamine D2 receptors (Kis = 188 and 142 nM, respectively); induces relaxation of isolated guinea pig ileum precontracted by substance P (EC50 = 0.6 μM); stimulates neurite outgrowth in primary murine striatal and cortical neurons at 100 nM

Formal name: 4-[1,1′-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-1-piperazinehexanamide

Synonyms: 

Molecular weight: 466.6

CAS: 1052147-86-0

Purity: ≥98%

Formulation: A solid

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