A flavonoid with diverse biological activities; inhibits Kv1.3-mediated currents

Loureirin B – 5 mg

Brand:
Cayman
CAS:
119425-90-0
Storage:
-20
UN-No:
Non-Hazardous - /

Loureirin B is a flavonoid originally isolated from D. cochinchinensis, a major component of the traditional herbal medicine dragon’s blood, and has diverse biological activities.{48437,48438,48439} It inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells.{48437} It also inhibits phytohemagglutinin-induced IL-2 release from these cells. Loureirin B (25 μg/ml) reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay.{48438} It reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue. Loureirin B increases glucose absorption and intracellular ATP levels in Ins-1 cells via inhibition of the KATP current and intracellular influx of calcium.{48439}  

 

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SKU: 27454 - 5 mg Category:

Description

A flavonoid with diverse biological activities; inhibits Kv1.3-mediated currents, induces membrane depolarization, and reduces calcium influx in Jurkat T cells; inhibits phytohemagglutinin-induced IL-2 release in Jurkat T cells; reduces type I collagen and fibronectin protein levels in TGF-β1-stimulated fibroblasts as well as contraction of TGF-β1-stimulated fibroblasts in a gel contraction assay at 25 μg/ml; reduces type I collagen and fibronectin protein levels and inhibits phosphorylation of ERK and JNK in isolated human hypertrophic scar tissue; increases glucose absorption and intracellular ATP levels in Ins-1 cells

Formal name: 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-1-propanone

Synonyms: 

Molecular weight: 316.4

CAS: 119425-90-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Flavonoids||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Adaptive Immunity

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