A physiologically active metabolite of losartan; a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms

Losartan Carboxylic Acid – 5 mg

Brand:
Cayman
CAS:
124750-92-1
Storage:
-20
UN-No:
Non-Hazardous - /

Losartan carboxylic acid is a physiologically active metabolite of losartan, produced by cytochrome P450 isoforms in the liver.{28030} Like the parent compound, losartan carboxylic acid is a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.{28032,28031,21001} When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan.{21001} However, the metabolite has very low oral bioavailability.{21001} Losartan, but not its metabolite, inhibits platelet aggregation in vitro.{20999}  

 

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Description

A physiologically active metabolite of losartan; a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation

Formal name: 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid

Synonyms:  E-3174|EXP-3174

Molecular weight: 436.9

CAS: 124750-92-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors

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