An intermediate aldehyde metabolite of losartan that does not block angiotensin receptors

Losartan Carboxaldehyde – 10 mg

Brand:
Cayman
CAS:
114798-36-6
Storage:
-20
UN-No:
Non-Hazardous - /

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan (Item No. 10006594). It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions.{30560} At 1 µM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α (Item No. 16010).{30560} Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 µM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.{30561,30559}  

 

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Description

An intermediate aldehyde metabolite of losartan that does not block angiotensin receptors, but instead inhibits COX-2 expression, blocks ICAM-1 mRNA upregulation, and COX-dependent generation of TXA2 and PGF2α; also acts as a partial agonist (EC50 = 17.1 µM) of PPARγ

Formal name: 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde

Synonyms:  DuP-167|EXP3179

Molecular weight: 420.9

CAS: 114798-36-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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