An internal standard for the quantification of loratadine by GC- or LC-MS

Loratadine-d5 – 500 µg

Brand:
Cayman
CAS:
1020719-57-6
Storage:
-20
UN-No:
Non-Hazardous - /

Loratadine-d5 is intended for use as an internal standard for the quantification of loratadine (Item No. 15625) by GC- or LC-MS. Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).{25629,22788,25628} It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.{25627} Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.  

 

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SKU: 25040 - 500 µg Category:

Description

An internal standard for the quantification of loratadine by GC- or LC-MS

Formal name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-2,3,4,5,5-d5)-1-piperidinecarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 387.9

CAS: 1020719-57-6

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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