A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs (ED50 = 0.40 mg/kg)

Loratadine – 10 mg

Brand:
Cayman
CAS:
79794-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

Loratadine is a non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM).{25629,22788,25628} It has been shown to inhibit the release of leukotriene C4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and to inhibit allergic bronchospasm in guinea pigs with an ED50 value of 0.40 mg/kg.{25627} Formulations containing loratadine have been used in the treatment of allergic rhinitis and chronic idiopathic urticaria.  

 

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Description

A non-sedating antihistamine that acts as a selective inverse agonist of peripheral histamine H1 receptors (Ki = 35 nM); inhibits the release of LTC4 (IC50 = 8 µM) and histamine (IC50 = 11 µM) from rodent mast cells and inhibits allergic bronchospasm in guinea pigs (ED50 = 0.40 mg/kg)

Formal name: 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylic acid, ethyl ester

Synonyms:  SCH 29851

Molecular weight: 382.9

CAS: 79794-75-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Innate Immunity

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