A potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme); inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM); reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 26.63 and 26.10 µM

Lopinavir – 250 mg

Brand:
Cayman
CAS:
192725-17-0
Storage:
-20
UN-No:
Non-Hazardous - /

Lopinavir is a potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme).{24199} It inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM). Lopinavir reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50s = 26.63 and 26.10 µM, respectively).{53655} It reduces lung and kidney viral load, bronchointerstitial pneumonia, and pulmonary inflammatory cell infiltration in a marmoset model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection when administered in combination with ritonavir (Item No. 13872).{53656}  

 

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Description

A potent HIV-1 protease inhibitor (Ki = 1.3 pM for wild-type enzyme); inhibits the replication of clinical isolates of HIV-1 (EC50s = 5-52 nM); reduces the infectious virus yield and viral RNA copy numbers in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC50s = 26.63 and 26.10 µM, respectively); reduces lung and kidney viral load, bronchointerstitial pneumonia, and pulmonary inflammatory cell infiltration in a marmoset model of MERS-CoV when administered in combination with ritonavir ,,

Formal name: N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-αS-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

Synonyms:  A-157378.0|ABT-378

Molecular weight: 628.8

CAS: 192725-17-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Protease Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Immunology & Inflammation|Pulmonary Diseases|COVID-19||Research Area|Immunology & Inflammation|Pulmonary Diseases|SARS||Research Area|Infectious Disease|Viral Diseases|Coronaviruses||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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