An HCV polymerase inhibitor (Ki = 17 nM); inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis; inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM)

Lomibuvir – 10 mg

Brand:
Cayman
CAS:
1026785-59-0
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Lomibuvir is a non-nucleoside inhibitor of the RNA-directed RNA polymerase of hepatitis C virus (HCV; Ki = 17 nM) that inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis.{48108} It inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM).  

 

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SKU: 26630 - 10 mg Category:

Description

An HCV polymerase inhibitor (Ki = 17 nM); inhibits primer-dependent RNA synthesis selectively over de novo RNA synthesis; inhibits HCV replication in Huh7.5 cells expressing the 1b/Con1 HCV subgenomic replicon (EC50 = 5 nM)

Formal name: 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid

Synonyms:  VX-222

Molecular weight: 445.6

CAS: 1026785-59-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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