A voltage-dependent calcium channel blocker; inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons (IC50s = 1.9 and 4 μM

Lomerizine (hydrochloride) – 1 g

Brand:
Cayman
CAS:
101477-54-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Lomerizine is a voltage-dependent calcium channel blocker that inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons with IC50 values of 1.9 and 4 μM, respectively.{53083,53084} It inhibits vasoconstriction induced by potassium chloride, serotonin (5-HT; Item No. 14332), or vasopressin in isolated rat basilar arteries when used at a concentration of 1 μM.{53083} Lomerizine (1 μM) reduces neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures.{53085} It reduces retinal damage in a rat model of retinal ischemia-reperfusion injury when administered at a dose of 1 mg/kg.  

 

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SKU: 28374 - 1 g Category:

Description

A voltage-dependent calcium channel blocker; inhibits low- and high-voltage activated calcium currents in rat hippocampal CA1 pyramidal neurons (IC50s = 1.9 and 4 μM, respectively); inhibits vasoconstriction induced by potassium chloride, 5-HT, or vasopressin in isolated rat basilar arteries at 1 μM; reduces neurotoxicity induced by glutamate, NMDA, or kainate in rat retinal primary cell cultures at 1 μM; reduces retinal damage in a rat model of retinal ischemia-reperfusion injury at 1 mg/kg

Formal name: 1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]-piperazine, dihydrochloride

Synonyms:  KB-2796

Molecular weight: 541.5

CAS: 101477-54-7

Purity: ≥98%

Formulation: A crystalline solid

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