An iridoid glycoside with diverse biological activities; reduces hydrogen peroxide-induced apoptosis in SH-SY5Y cells from 0.25-12.5 µM; inhibits COX-1 activity (IC50 = 3.55 µM)

Loganin – 10 mg

Brand:
Cayman
CAS:
18524-94-2
Storage:
-20
UN-No:
Non-Hazardous - /

Loganin is an iridoid glycoside that has been found in C. fructus and has diverse biological activities.{32245,32247,57095,57096} It reduces hydrogen peroxide-induced apoptosis in SH-SY5Y cells when used at concentrations ranging from 0.25 to 12.5 µM.{32245} Loganin inhibits COX-1 activity (IC50 = 3.55 µM), as well as LPS-induced TNF-α formation (IC50 = 154.6 µM) in RAW 264.7 cells.{32247} In vivo, loganin (20 and 100 mg/kg) reduces food intake, blood glucose levels, and serum triglyceride levels, as well as increases serum HDL levels in db/db diabetic mice.{57095} It attenuates scopolamine-induced memory deficits in the Morris water maze and passive avoidance test in mice.{57096} Loganin (20 and 1,000 mg/kg) reduces serum and kidney advanced glycation end-product (AGE) and malondialdehyde (MDA) levels and improves renal function in a mouse model of diabetic nephropathy.{57097}  

 

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Description

An iridoid glycoside with diverse biological activities; reduces hydrogen peroxide-induced apoptosis in SH-SY5Y cells from 0.25-12.5 µM; inhibits COX-1 activity (IC50 = 3.55 µM), as well as LPS-induced TNF-α formation (IC50 = 154.6 µM) in RAW 264.7 cells; reduces food intake, blood glucose levels, and serum triglyceride levels, as well as increases serum HDL levels in db/db diabetic mice at 20 and 100 mg/kg; attenuates scopolamine-induced memory deficits in the Morris water maze and passive avoidance test in mice; reduces serum and kidney AGE and MDA levels and improves renal function in a mouse model of diabetic nephropathy at 20 and 1,000 mg/kg

Formal name: 1-(β-D-glucopyranosyloxy)-1S,4aS,5,6S,7R,7aS-hexahydro-6-hydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid, methyl ester

Synonyms:  7-hydroxy-6-desoxy Verbenalin|NSC 606403

Molecular weight: 390.4

CAS: 18524-94-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Glycosides||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Cyclooxygenases||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Carbohydrate Oxidation||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation

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