A PDI inhibitor (Kd = 62 nM); inhibits PDI chaperone activity in an insulin aggregation assay at 75 µM; reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM); reduces MSN degeneration in a rat postnatal cortical brain slice model of mHTTQ73-induced Huntington’s disease

LOC14 – 50 mg

Brand:
Cayman
CAS:
877963-94-5
Storage:
-20
UN-No:
Non-Hazardous - /

LOC14 is an inhibitor of protein disulfide isomerase (PDI; Kd = 62 nM).{28805} It inhibits PDI chaperone activity in an insulin aggregation assay when used at a concentration of 75 µM. LOC14 reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM). It reduces medium spiny neuron (MSN) degeneration in a rat postnatal cortical brain slice model of mHTTQ73-induced Huntington’s disease.  

 

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Description

A PDI inhibitor (Kd = 62 nM); inhibits PDI chaperone activity in an insulin aggregation assay at 75 µM; reduces PC12 cell death induced by the misfolded huntingtin protein mHTTQ103 (EC50 = 500 nM); reduces MSN degeneration in a rat postnatal cortical brain slice model of mHTTQ73-induced Huntington’s disease

Formal name: 2-[[4-(cyclopropylcarbonyl)-1-piperazinyl]methyl]-1,2-benzisothiazol-3(2H)-one

Synonyms: 

Molecular weight: 317.4

CAS: 877963-94-5

Purity: ≥90%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease

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