An alkaloid with diverse biological activities; binds to nAChRs in rat brain homogenates (Ki = 4 nM); has antinociceptive effects in the tail-flick assay in mice; reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats at 0.3 and 0.9 mg/kg; decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test at 1 and 4 mg/kg

(–)-Lobelin (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
134-63-4
Storage:
-20
UN-No:
De Minimis - 1544 / 6.1

(–)-Lobeline is an alkaloid that has been found in Lobelia and has diverse biological activities.{53242,53243,53244} It binds to nicotinic acetylcholine receptors (nAChRs) in rat brain homogenates (Ki = 4 nM) and has antinociceptive effects in the tail-flick assay in mice.{53242} (–)-Lobeline (0.3 and 0.9 mg/kg) reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats.{53243} It also decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test, indicating antidepressant-like activity, in mice when administered at doses of 1 and 4 mg/kg.{53244}  

 

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SKU: 29526 - 500 mg Category:

Description

An alkaloid with diverse biological activities; binds to nAChRs in rat brain homogenates (Ki = 4 nM); has antinociceptive effects in the tail-flick assay in mice; reduces the number of errors in a repeated acquisition procedure in the radial arm maze in rats at 0.3 and 0.9 mg/kg; decreases immobility time in the forced swim test and feeding latency in the novelty suppressed feeding test at 1 and 4 mg/kg

Formal name: 2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-ethanone, monohydrochloride

Synonyms:  (–)-α-Lobeline|VUF 10751

Molecular weight: 373.9

CAS: 134-63-4

Purity: ≥95%

Formulation: A solid

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