A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia

Lobaric Acid – 500 µg

Brand:
Cayman
CAS:
522-53-2
Storage:
-20
UN-No:
Non-Hazardous - /

Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites.{42123,42124,42125,42126,42127,42128} It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml).{42124,42125} Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the human recombinant enzyme) and production of 12(S)-HETE (Item No. 34570) by 12(S)-lipoxygenase (IC50 = 28.5 μM).{42127,42128} In vivo, lobaric acid (250 μM) decreases lesion number, but not lesion diameter, in tobacco leaves infected with tobacco mosaic virus (TMV).{42126}  

 

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SKU: 25205 - 500 µg Category:

Description

A depsidone metabolite; scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol); inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml); inhibits PTP1B (IC50 = 0.87 μM); inhibits 12(S)-HETE production by 12(S)-lipoxygenase (IC50 = 28.5 μM); decreases lesion number, but not lesion diameter, in TMV-infected tobacco leaves (250 μM),

Formal name: 8-hydroxy-3-methoxy-11-oxo-1-(1-oxopentyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid

Synonyms: 

Molecular weight: 456.5

CAS: 522-53-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Plant Biology|Phytoprotectants

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