An inhibitor of LMW-PTPA (IC50 = 0.8 µM); selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by >50% at 40 µM; increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 µM; improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day

LMW-PTP Inhibitor I – 5 mg

Brand:
Cayman
CAS:
1908414-82-3
Storage:
-20
UN-No:
Non-Hazardous - /

LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 µM).{34480} It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 µM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 µM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day.  

 

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Description

An inhibitor of LMW-PTPA (IC50 = 0.8 µM); selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by >50% at 40 µM; increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 µM; improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day

Formal name: N,N-diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]-benzamide

Synonyms:  LMPTP Inhibitor I|MLS-0322825 Cmpd 23

Molecular weight: 444.6

CAS: 1908414-82-3

Purity: ≥98%

Formulation: A crystalline solid

Application|Enzyme Activity||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes

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