An HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM

LMK 235 – 1 mg

Brand:
Cayman
CAS:
1418033-25-6
Storage:
-20
UN-No:
Non-Hazardous - /

Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues, which commonly results in chromatin condensation and transcriptional repression.{12365,12366} LMK 235 is an HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM, respectively) over other HDACs (IC50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively).{30765} It displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA (Item No. 10009929) or trichostatin A (Item No. 89730).{30765} LMK 235 and derivatives inhibit the growth of the malarial parasite P. falciparum at multiple life cycle stages at nanomolar concentrations.{30764}  

 

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Description

An HDAC inhibitor that selectively targets HDACs 4 and 5 (IC50s = 12 and 4 nM, respectively) over other HDACs (IC50s = 56, 320, 850, 880, and 1,280 for HDACs 6, 1, 11, 2, and 8, respectively); displays enhanced cytotoxic effects against human cancer cell lines, compared to SAHA or TSA

Formal name: N-[[6-(hydroxyamino)-6-oxohexyl]oxy]-3,5-dimethyl-benzamide

Synonyms: 

Molecular weight: 294.4

CAS: 1418033-25-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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