An activator of TrkB and TrkC; selective for TrkB and TrkC over TrkA in NIH-3T3 cells but does inhibit the 5-HT5A receptor and dopamine transporter by >50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM; increases survival

LM22B-10 – 5 mg

Brand:
Cayman
CAS:
342777-54-2
Storage:
-20
UN-No:
Non-Hazardous - /

LM22B-10 is an activator of neurotrophic tyrosine kinase receptor 2 (TrkB) and -3 (TrkC).{45544} It is selective for TrkB and TrkC over TrkA in NIH3T3 cells but does inhibit the serotonin (5-HT) receptor subtype 5-HT5A and the dopamine transporter by greater than 50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM. LM22B-10 increases survival, neurite length, and dendritic spine density of primary mouse embryonic hippocampal neurons when used at a concentration of 1 µM. LM22B-10 (50 mg/kg i.p. in combination with an intranasal dose of 5 mg/kg per day) also increases hippocampal neuron dendritic spine density in aged mice.  

 

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SKU: 29037 - 5 mg Category:

Description

An activator of TrkB and TrkC; selective for TrkB and TrkC over TrkA in NIH-3T3 cells but does inhibit the 5-HT5A receptor and dopamine transporter by >50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM; increases survival, neurite length, and dendritic spine density of primary mouse embryonic hippocampal neurons at 1 µM; increases hippocampal neuron dendritic spine density in aged mice at 50 mg/kg i.p. in combination with an intranasal dose of 5 mg/kg per day

Formal name: 2,2′,2”,2”’-[[(4-chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis-ethanol

Synonyms: 

Molecular weight: 485

CAS: 342777-54-2

Purity: ≥98%

Formulation: A crystalline solid

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