A cell-permeable ligand of Survivin that blocks its interaction with Ran

LLP-3 – 1 mg

Brand:
Cayman
CAS:
1453835-43-2
Storage:
-20
UN-No:
Non-Hazardous - /

Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins.{18220,12862} LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM).{30789} It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.{30789}  

 

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Description

A cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis in glioma stem cells (IC50 = 31 µM); abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures

Formal name: 4-​[3,​5-​bis(phenylmethoxy)​phenyl]​-​6-​(5-​chloro-​2-​hydroxyphenyl)​-​1,​2-​dihydro-​2-​oxo-3-​pyridinecarbonitrile​

Synonyms: 

Molecular weight: 535

CAS: 1453835-43-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cancer Stem Cell Research||Research Area|Cancer|Cell Death|Apoptosis

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