Description
An antimicrobial peptide; inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium; binds sheep erythrocytes coated with S. minnesota Re-LPS and induces agglutination (MAC = 12.1 μg/ml); chemoattractant for, and can induce calcium mobilization in, human monocytes, neutrophils, and T cells that express FPRL1; pretreatment reduces DENV-2 infectivity as well as levels of viral genomic RNA and NS1 antigen (10-15 μM); inhibits cecal ligation and puncture-induced caspase-1 activation and pyroptosis of peritoneal macrophages, reduces levels of inflammatory cytokines, and improves survival in polybacterial septic mice
Formal name: L-leucyl-L-leucylglycyl-L-α-aspartyl-L-phenylalanyl-L-phenylalanyl-L-arginyl-L-lysyl-L-seryl-L-lysyl-L-α-glutamyl-L-lysyl-L-isoleucylglycyl-L-lysyl-L-α-glutamyl-L-phenylalanyl-L-lysyl-L-arginyl-L-isoleucyl-L-valyl-L-glutaminyl-L-arginyl-L-isoleucyl-L-lysyl-L-α-aspartyl-L-phenylalanyl-L-leucyl-L-arginyl-L-asparaginyl-L-leucyl-L-valyl-L-prolyl-L-arginyl-L-threonyl-L-α-glutamyl-L-serine, trifluoroacetate salt
Synonyms: CAP-18|Cathelicidin|FALL-39|hCAP-18
Molecular weight: 4,493.30
CAS: 154947-66-7
Purity: ≥95%
Formulation: A lyophilized powder
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Peptides||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis||Research Area|Infectious Disease|Viral Diseases|Dengue
