Description
LL-37 is an antimicrobial peptide cleaved from the only described human cathelicidin, hCAP18. Production of LL-37 is activated by M. tuberculosis infection in neutrophils and epithelial cells of the lung. {17198} LL-37 is a component of neutrophil extracellular traps (NETs), and its presence on NETs has been associated with the activation of inflammation and NLRP3 inflammasomes. {26640} Autoimmune disorders such as systemic lupus erythematosus have been associated with the generation of autoantibodies against NET proteins. {26640} LL-37 has a predicted molecular weight of 5 kDa; Cayman’s LL-37 Polyclonal Antibody detects a 5 kDa band, as well as an 18 kDa band corresponding to the hCAP18 precursor to LL-37.
Synonyms: Antibacterial Protein LL-37
Immunogen: Synthetic human LL-37 antimicrobial peptide
Formulation: 500 µl of peptide-affinity purified IgG
Isotype:
Applications: WB
Origin:
Stability: 365 days
Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Immunology & Inflammation|Autoimmunity|Lupus||Research Area|Immunology & Inflammation|Innate Immunity|NETosis||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis
