An inhibitor of RSKs (IC50s = 6

LJH685 – 5 mg

Brand:
Cayman
CAS:
1627710-50-2
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LJH685 is an inhibitor of p90 ribosomal S6 kinases (RSKs, also known as MAP kinase-activated protein kinases, or MAPKAPKs) that inhibits RSK1, 2, and 3 in vitro with IC50 values of 6, 5, and 4 nM, respectively.{33573} It is selective for RSKs over a panel of 96 other kinases. LJH685 blocks RSK activity in cells, preventing phosphorylation of y-box-binding protein 1 on Ser102.{33573} The inhibition of RSK activity correlates with antiproliferative effects in MAPK pathway-dependent cancer cell lines, but only in an anchorage-independent growth setting.{33573}  

 

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SKU: 19913 - Category:

Description

An inhibitor of RSKs (IC50s = 6, 5, and 4 nM for RSK1, 2, and 3, respectively in vitro); blocks RSK activity in cells

Formal name: 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-phenol

Synonyms: 

Molecular weight: 381.4

CAS: 1627710-50-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|S6K Signaling

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