An ACE inhibitor (IC50 = 1.2 nM); reduces the formation of endothelin-1 and increases NO in human vascular endothelial cells at 0.1 nM; inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 µg/kg

Lisinopril – 500 mg

Brand:
Cayman
CAS:
76547-98-3
Storage:
-20
UN-No:
Non-Hazardous - /

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM).{16807} It reduces the formation of endothelin-1 (Item No. 24127) and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM.{16847} Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 µg/kg, respectively).{16807}  

 

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Description

An ACE inhibitor (IC50 = 1.2 nM); reduces the formation of endothelin-1 and increases NO in human vascular endothelial cells at 0.1 nM; inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 µg/kg, respectively)

Formal name: N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline

Synonyms:  MK-521|MK-522

Molecular weight: 405.5

CAS: 76547-98-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Angiotensin-converting Enzyme||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Vasculature|Vasodilation

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