A ferroptosis inhibitor; inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in inducible Gpx4-/- MEFs at 50 nM; inhibits ferroptosis induced by the ferroptosis-inducing agents BSO

Liproxstatin-1 – 25 mg

Brand:
Cayman
CAS:
950455-15-9
Storage:
-20
UN-No:
Non-Hazardous - /

Liproxstatin-1 is a ferroptosis inhibitor.{28622} It inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in mouse embryonic fibroblasts (MEFs) with an inducible knockdown of glutathione peroxidase 4 (Gpx4-/- MEFs) when used at a concentration of 50 nM. Liproxstatin-1 also inhibits ferroptosis induced by the ferroptosis-inducing agents L-buthionine sulphoximine (BSO), erastin (Item No. 17754), and (1S,3R)-RSL3 (Item No. 19288) in a concentration-dependent manner in MEFs, but does not inhibit necroptosis, apoptosis, or necrosis. It inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells. Liproxstatin-1 (10 mg/kg) increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice and reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury. It is also an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals.{43395}  

 

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Description

A ferroptosis inhibitor; inhibits ferroptotic cell death (IC50 = 22 nM) and lipid peroxidation in inducible Gpx4-/- MEFs at 50 nM; inhibits ferroptosis induced by the ferroptosis-inducing agents BSO, erastin, and (1S,3R)-RSL3 in a concentration-dependent manner in MEFs; inhibits cell death and lipid peroxidation induced by (1S,3R)-RSL3 in human renal proximal tubule epithelial cells; increases survival and decreases TUNEL+ kidney cells in inducible Gpx4-/- mice at 10 mg/kg; reduces tissue injury in a mouse model of hepatic ischemia/reperfusion injury; an antioxidant that inhibits autooxidation of lipids by trapping peroxyl radicals

Formal name: N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2′(1’H)-​quinoxalin]-3′-amine

Synonyms: 

Molecular weight: 340.9

CAS: 950455-15-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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