A trihydroxy fatty acid containing a conjugated tetraene produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes; promotes leukocyte activation

Lipoxin A4 – 25 µg

Brand:
Cayman
CAS:
89663-86-5
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE (Item No. 34700) or 15-HpETE with human leukocytes.{352} LXA4 is equipotent to leukotriene B4 (Item No. 20110) in inducing superoxide generation in human neutrophils at 0.1 µM.{350} LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.{350,354,2722} Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.{14569}  

 

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SKU: 90410 - 25 µg Category:

Description

A trihydroxy fatty acid containing a conjugated tetraene produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes; promotes leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion

Formal name: 5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid

Synonyms:  5(S),6(R),15(S)-TriHETE|LXA4

Molecular weight: 352.5

CAS: 89663-86-5

Purity: ≥95%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Lipoxins/Resolvin Es||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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