An inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells); inhibits uptake of long- and very long-chain

Lipofermata – 25 mg

Brand:
Cayman
CAS:
297180-15-5
Storage:
-20
UN-No:
Non-Hazardous - /

Lipofermata is an inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells).{36945} It inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM).{36946} Lipofermata inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of reactive oxygen species (ROS) and reverses decreases in glutathione (GSH) levels induced by palmitate (Item No. 10010279) in HepG2 and INS-1E cells. In vivo, lipofermata (500 mg/kg) inhibits absorption of 13C-oleate in mice.  

 

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SKU: 25869 - 25 mg Category:

Description

An inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells); inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM); inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of ROS and reverses decreases in GSH levels induced by palmitate in HepG2 and INS-1E cells; inhibits absorption of 13C-oleate in mice at 500 mg/kg

Formal name: 5-bromo-5′-phenyl-spiro[3H-indole-3,2′(3’H)-[1,3,4]thiadiazol]-2(1H)-one

Synonyms: 

Molecular weight: 360.2

CAS: 297180-15-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Lipid Biochemistry|Fatty Acids

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