An endocannabinoid that contains linoleate in place of the arachidonate moiety of AEA; has been detected in porcine brain and murine peritoneal macrophages and has weak affinity for the CB1 and CB2 receptors (Kis =10 µM and 25 µM

Linoleoyl Ethanolamide – 100 mg

Brand:
Cayman
CAS:
68171-52-8
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

Linoleoyl ethanolamide is an endocannabinoid detected in porcine brain and murine peritoneal macrophages which contains linoleate in place of the arachidonate moiety of arachidonyl ethanolamide (AEA).{11172,11151} It has weak affinity for the cannabinoid 1 (CB1) and CB2 receptors, exhibiting Ki values of 10 µM and 25 µM, respectively.{7422} However, it is only approximately 4-fold less potent than AEA at causing catalepsy in mice (ED50 of 26.5 mg/kg).{11177} In addition, linoleoyl ethanolamide increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner.{11152} However, cellular toxicity is readily apparent at concentrations of 10-20 µM. Linoleoyl ethanolamide inhibits human fatty acid amide hydrolase-dependent hydrolysis of AEA with a Ki value of 9.0 µM, but also is hydrolyzed effectively by the enzyme.{7251,3922}  

 

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SKU: 90155 - 100 mg Category:

Description

An endocannabinoid that contains linoleate in place of the arachidonate moiety of AEA; has been detected in porcine brain and murine peritoneal macrophages and has weak affinity for the CB1 and CB2 receptors (Kis =10 µM and 25 µM, respectively); 4-fold less potent than AEA at causing catalepsy in mice (ED50 = 26.5 mg/kg); increases ERK phosphorylation and AP-1-dependent transcription approximately 1.5 fold at 15 µM in a CB-receptor-independent manner; inhibits human FAAH-dependent hydrolysis of AEA (Ki = 9.0 µM), but is also effectively hydrolyzed by the enzyme

Formal name: N-(2-hydroxyethyl)-9Z,12Z-octadecadienamide

Synonyms:  LEA

Molecular weight: 323.5

CAS: 68171-52-8

Purity: ≥98%

Formulation: A solution in ethanol

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