An antibiotic active against Gram-positive bacteria

Linezolid – 50 mg

Brand:
Cayman
CAS:
165800-03-3
Storage:
-20
UN-No:
Non-Hazardous - /

Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).{22653} Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.{36681} Formulations containing linezolid have been used to treat MRSA infections.  

 

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Description

An antibiotic active against Gram-positive bacteria, including resistant species (MICs = 2-4 mg/ml); inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes; reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits at 50 mg/kg

Formal name: N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide

Synonyms:  PNU 100766

Molecular weight: 337.4

CAS: 165800-03-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Oxazolidinones||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA

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