An internal standard for the quantification of limaprost by GC- or LC-MS

Limaprost-d3 – 500 µg

Brand:
Cayman
CAS:
1263190-37-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost (Item No. 13810) by GC- or LC-MS. Limaprost is an analog of prostaglandin E1 (PGE1; Item No. 13010) with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen-induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.{6808}  

 

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SKU: 25416 - 500 µg Category:

Description

An internal standard for the quantification of limaprost by GC- or LC-MS

Formal name: (E)-7-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-(methyl-d3)non-1-en-1-yl)-5-oxocyclopentyl)hept-2-enoic acid

Synonyms:  17α,20-dimethyl-Δ2-PGE1-d3|17α,20-dimethyl-Δ2-Prostaglandin E1-d3

Molecular weight: 383.5

CAS: 1263190-37-9

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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