Description
An inhibitor of the PD-1/PD-L1 protein interaction (IC50 = 3 nM in an HTRF assay); increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 79 and 763 nM, respectively, in reporter assays)
Formal name: N,N’-(((((((2,2′-dimethyl-[1,1′-biphenyl]-3,3′-diyl)bis(methylene))bis(oxy))bis(2-((5-cyanopyridin-3-yl)methoxy)-5-methyl-4,1-phenylene))bis(methylene))bis(azanediyl))bis(ethane-2,1-diyl))diacetamide
Synonyms:
Molecular weight: 915.1
CAS: 2375720-38-8
Purity: ≥98%
Formulation: A crystalline solid
