Description
An inhibitor of the PD-1/PD-L1 protein interaction (IC50 = 25 nM in a HTRF assay); increases the activation of Jurkat cells expressing PD-1 in co-culture with U2OS or CHO cells expressing PD-L1 (EC50s = 334 and 4,214 nM, respectively, in reporter assays)
Formal name: N,N′-[(2,2′-dimethyl[1,1′-biphenyl]-3,3′-diyl)bis[methyleneoxy(6-methoxy-2,5-pyridinediyl)methyleneimino-2,1-ethanediyl]]bis-acetamide
Synonyms:
Molecular weight: 684.8
CAS: 2182653-84-3
Purity: ≥95%
Formulation: A crystalline solid
