A calcium sensitizer that causes increased cardiac contractility by binding troponin C (EC50 = 9 nM)

Levosimendan – 500 mg

Brand:
Cayman
CAS:
141505-33-1
Storage:
-20
UN-No:
Non-Hazardous - /

Levosimendan is a calcium sensitizer that can cause increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes.{26307,26308} It also has been reported to inhibit phosphodiesterases 3 and 4 in left ventricular cardiac tissue with IC50 values of 2.5 nM and 25 µM, respectively.{26309}  

 

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Description

A calcium sensitizer that causes increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes; also inhibits phosphodiesterases 3 and 4 (IC50s =2.5 nM and 25 µM, respectively)

Formal name: 2-[2-[4-[(4R)-1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl]phenyl]hydrazinylidene]-propanedinitrile

Synonyms:  (R)-Simendan|OR 1259|Simdax®

Molecular weight: 280.3

CAS: 141505-33-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphodiesterases||Research Area|Cardiovascular System|Heart|Myocardial Contractility

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