A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 µg/kg); in combination with mepivacaine

Levonordefrin – 100 mg

Brand:
Cayman
CAS:
829-74-3
Storage:
-20
UN-No:
Non-Hazardous - /

Levonordefrin is the (–)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Item No. 16673), that acts as a vasoconstrictor.{39580} Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer.{39581} It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Item No. 23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%.{39582} Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.  

 

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SKU: 23993 - 100 mg Category:

Description

A vasoconstrictor; (–)-enantiomer of nordefrin; rapidly increases blood pressure and heart rate in anesthetized dogs (1-5 µg/kg); in combination with mepivacaine, increases systolic arterial blood pressure in anesthetized dogs (0.514 and 1.542 mg/kg)

Formal name: 4-[(1R,2S)-2-amino-1-hydroxypropyl]-1,2-benzenediol

Synonyms:  (–)-3,4-dihydroxy Norephedrine|(–)-α-methyl Noradrenaline|Corbadrine

Molecular weight: 183.2

CAS: 829-74-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Cardiovascular System|Vasculature|Vasoconstriction

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