A 5-HT and NE reuptake inhibitor (Kis = 11.2 and 92.2 nM

Levomilnacipran (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
175131-60-9
Storage:
-20
UN-No:
Non-Hazardous - /

Levomilnacipran is an active enantiomer of the serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor milnacipran (Item No. 23837).{36661} It binds to the 5-HT and NE transporters (Kis = 11.2 and 92.2 nM, respectively, for human recombinant transporters) and inhibits reuptake in vitro (IC50s = 19 and 10.5 nM, respectively). It is selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM for human recombinant DAT) and 23 receptors (Kis = ≥10,000 nM). Levomilnacipran increases extracellular levels of 5-HT and NE in rat cortex with minimal effective doses (MEDs) of 20 and 10 mg/kg, respectively. It decreases immobility in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively) without increasing locomotor activity. Formulations containing levomilnacipran have been used in the treatment of major depressive disorder.  

 

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Description

A 5-HT and NE reuptake inhibitor (Kis = 11.2 and 92.2 nM, respectively; IC50s = 19 and 10.5 nM, respectively); selective for 5-HT and NE transporters over DAT (Ki = >10,000 nM) and 23 receptors (Kis = ≥10,000 nM; increases extracellular 5-HT and NE in rat cortex (MEDs = 20 and 2.5 mg/kg); decreases immobility time in the forced swim and tail suspension tests (MEDs = 20 and 2.5 mg/kg, respectively)

Formal name: 2R-(aminomethyl)-N,N-diethyl-1S-phenyl-cyclopropanecarboxamide, monohydrochloride

Synonyms:  (1S-cis)-Milnacipran

Molecular weight: 282.8

CAS: 175131-60-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Neuroscience|Behavioral Neuroscience|Depression

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