Metabolite of LTD4 and one of the constituents of SRS-A; considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of CysLTs; urinary excretion of LTE4 is often used as an indicator of asthma

Leukotriene E4 – 25 µg

Brand:
Cayman
CAS:
75715-89-8
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4, leaving only the cysteinyl group still attached to the fatty acid backbone.{2236} It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A).{394} LTE4 is considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of cysteinyl leukotrienes.{2236,396} Unlike LTC4 and LTD4, LTE4 accumulates in both plasma and urine. Therefore, urinary excretion of LTE4 is often used as an indicator of asthma.{1815,865,2064} In humans, basal levels of LTE4 range from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels increase to 80-1,000 pg/mg creatinine.{865}  

 

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Description

Metabolite of LTD4 and one of the constituents of SRS-A; considerably less active (8 to 12-fold) than LTC4 in the biological activities characteristic of CysLTs; urinary excretion of LTE4 is often used as an indicator of asthma

Formal name: 5S-hydroxy-6R-(S-cysteinyl)-7E,9E,11Z,14Z-eicosatetraenoic acid

Synonyms:  LTE4

Molecular weight: 439.6

CAS: 75715-89-8

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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