An internal standard for the quantification of LTD4 by GC- or LC-MS.

Leukotriene D4-d5 – 25 µg

Brand:
Cayman
CAS:
1240398-17-7
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Leukotriene D4-d5 (LTD4-d5) contains five deuterium atoms at the 19, 19′, 20, 20 and 20 positions. It is intended for use as an internal standard for the quantification of LTD4 by GC- or LC-mass spectrometry. LTD4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase.{541,589} It is the first cysteinyl leukotriene metabolite of LTC4. Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity.{4157,482} LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of peripheral airway smooth muscle.{396,392}  

 

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SKU: 10006199 - 25 µg Category:

Description

An internal standard for the quantification of LTD4 by GC- or LC-MS.

Formal name: 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11Z,14Z-eicosatetraenoic-19,19,20,20,20-d5 acid

Synonyms:  LTD4-d5

Molecular weight: 501.7

CAS: 1240398-17-7

Purity: ≥99% deuterated forms (d1-d5)

Formulation: A solution in ethanol

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Leukotrienes||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Fatty Acids||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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