A leukotriene; metabolite of EPA formed through 5-LO pathway; increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner; reduces tumor volume in mice injected with Tm1 murine melanoma cells (100 nM); elicits chemokinesis and lysosomal enzyme release from PMNLs; induces platelet aggregation

Leukotriene B5 – 500 µg

Brand:
Cayman
CAS:
80445-66-5
Storage:
-20
UN-No:
Excepted Quantity - 1170 / 3

Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities.{36392,36393,551,2238,330} It is a metabolite of eicosapentaenoic acid (EPA; Item Nos. 90110 | 90110.1 | 21908) formed through the 5-lipoxygenase (5-LO) pathway.{719} LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.{36392} In vivo, LTB5 (100 nM) reduces tumor volume in mice injected with Tm1 murine melanoma cells.{36393} LTB5 also elicits chemokinesis and lysosomal enzyme release from polymorphonuclear leukocytes (PMNLs) 20- to 30-fold less, and induces platelet aggregation 8-fold less, potently than LTB4 (Item No. 20110).{551,2238,330}  

 

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Description

A leukotriene; metabolite of EPA formed through 5-LO pathway; increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner; reduces tumor volume in mice injected with Tm1 murine melanoma cells (100 nM); elicits chemokinesis and lysosomal enzyme release from PMNLs; induces platelet aggregation

Formal name: 5S,12R-dihydroxy-6Z,8E,10E,14Z,17Z-eicosapentaenoic acid

Synonyms:  LTB5

Molecular weight: 334.5

CAS: 80445-66-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cancer||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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