A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM)

Leukotriene B4 Ethanolamide – 50 µg

Brand:
Cayman
CAS:
877459-63-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2.{4425,8280} LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4-EA was a potent antagonist with about three times greater affinity for the receptor than LTB4 (Ki = 1.22 nM versus 3.88 nM). LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with an EC50 of 10 nM.{11188} LTB4-EA thus represents a potential endogenous anti-inflammatory compound functioning as a natural antagonist of BLTR1.  

 

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Description

A theoretical 5-LO metabolite of AEA; acts as a potent antagonist of the human BLT1 receptor (Ki = 1.22 nM)

Formal name: N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide

Synonyms:  LTB4-EA

Molecular weight: 379.5

CAS: 877459-63-7

Purity: ≥97%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Leukotrienes||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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