An allosteric activator of CD11b/CD18; increases K562 cell adhesion to fibrinogen (EC50 = 4 µM); reduces rolling velocity of leukocytes

Leukadherin 1 – 10 mg

Brand:
Cayman
CAS:
344897-95-6
Storage:
-20
UN-No:
Non-Hazardous - /

Leukadherin 1 is a small molecule allosteric activator of CD11b/CD18 that increases K562 cell adhesion to an endogenous CD11b/CD18 ligand, fibrinogen (EC50 = 4 µM).{36188} It increases adhesion and decreases de-adhesion of murine neutrophils, leading to reduced chemotaxis. It acts by reducing the rolling velocity of leukocytes in mouse cremaster muscle, decreasing the number of leukocytes recruited to injured tissue. Leukadherin 1 is anti-inflammatory in a zebrafish tailfin injury model and a mouse model of anti-glomerular basement membrane nephritis. It also competitively inhibits YopH (Ki = 1.94 µM), a tyrosine phosphorylase secreted by Y. pestis into immune cells to block signal transduction, and anthrax lethal factor metalloproteinase, a component of anthrax toxin (IC50 = 6 µM).{36189,36187}  

 

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An allosteric activator of CD11b/CD18; increases K562 cell adhesion to fibrinogen (EC50 = 4 µM); reduces rolling velocity of leukocytes, decreasing the number of leukocytes recruited to injured tissue; anti-inflammatory in a zebrafish tailfin injury model and a mouse model of nephritis; competitively inhibits YopH (Ki = 1.94 µM) and anthrax lethal factor metalloproteinase (IC50 = 6 µM)

Formal name: 4-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid

Synonyms: 

Molecular weight: 421.5

CAS: 344897-95-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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