A nootropic and neuroprotective agent and a derivative of hypoxanthine; enhances NGF-induced neurite growth in PC12 cells at 10 and 100 µM and increases the production of synaptophysin at 5-100 ng/ml; enhances working memory in a win-shift T-maze in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate age-induced memory deficits at 30 mg/kg; reduces impairments in locomotor function in rats and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord at 60 mg/kg per day for 21 days in a rat model of spinal crush injury; reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1

Leteprinim (potassium salt) – 1 mg

Brand:
Cayman
CAS:
192564-13-9
Storage:
-20
UN-No:
Non-Hazardous - /

Leteprinim is a nootropic and neuroprotective agent and a derivative of hypoxanthine (Item No. 22254).{42986,42987,42988} Leteprinim (10 and 100 µM) enhances nerve growth factor induced neurite growth in PC12 cells and increases the production of synaptophysin when used at concentrations ranging from 5 to 100 ng/ml.{42986,42988} It enhances working memory in a win-shift T-maze test in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate, but not severe, age-induced memory deficits when administered at a dose of 30 mg/kg.{42989} In a rat model of spinal crush injury, leteprinim (60 mg/kg per day for 21 days) reduces impairments in locomotor function and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord.{42987} It reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1, CA3, and dentate gyrus regions and decreases the number of caspase-3 and TUNEL-positive cells in the hippocampus and prefrontal and parietal cortices in neonatal rats when administered at a dose of 60 mg/kg.{42990}  

 

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Description

A nootropic and neuroprotective agent and a derivative of hypoxanthine; enhances NGF-induced neurite growth in PC12 cells at 10 and 100 µM and increases the production of synaptophysin at 5-100 ng/ml; enhances working memory in a win-shift T-maze in young mice and reduces time delay-induced working memory errors in old mice with mild or moderate age-induced memory deficits at 30 mg/kg; reduces impairments in locomotor function in rats and reduces increases in the amount of necrotic tissue and the number of reactive astrocytes in the spinal cord at 60 mg/kg per day for 21 days in a rat model of spinal crush injury; reduces hypoxia-induced decreases in neuronal density in the hippocampal CA1, CA3, and dentate gyrus regions and decreases the number of caspase-3 and TUNEL-positive cells in the hippocampus and prefrontal and parietal cortices in neonatal rats at 60 mg/kg

Formal name: 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-benzoic acid, monopotassium salt

Synonyms:  AIT 082

Molecular weight: 365.4

CAS: 192564-13-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neuroprotection

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