A URAT1 inhibitor (IC50s = 3.5 and 81 µM for human and rat transporters

Lesinurad – 25 mg

Brand:
Cayman
CAS:
878672-00-5
Storage:
-20
UN-No:
Non-Hazardous - /

Lesinurad is an inhibitor of urate anion transporter 1 (URAT1; IC50s = 3.5 and 81 µM for human and rat transporters, respectively), a transporter that prevents renal urate resorption.{41221} It decreases uptake of urate by MDCK cells transfected with human URAT1.{41222} Lesinurad (80 mg/kg) also decreases serum levels of uric acid and urea nitrogen in a rat model of gout. Formulations containing lesinurad have been used in combination with other compounds in the treatment of gout.  

 

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SKU: 23688 - 25 mg Category:

Description

A URAT1 inhibitor (IC50s = 3.5 and 81 µM for human and rat transporters, respectively); decreases uptake of urate in vitro; decreases serum levels of uric acid and urea nitrogen in a rat model of gout when administered at a dose of 80 mg/kg

Formal name: 2-[[5-bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid

Synonyms: 

Molecular weight: 404.3

CAS: 878672-00-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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