A dihydropyridine L-type calcium channel blocker; binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM

Lercanidipine (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
132866-11-6
Storage:
-20
UN-No:
Non-Hazardous - /

Lercanidipine is a dihydropyridine L-type calcium channel blocker.{46593} It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure (DBP) in normotensive and spontaneously hypertensive rats with ED25 values of 16.3 and 15.5 µg/kg, respectively. Formulations containing lercanidipine have been used in the treatment of hypertension.  

 

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Description

A dihydropyridine L-type calcium channel blocker; binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM); reduces DBP in normotensive and spontaneously hypertensive rats (ED25s = 16.3 and 15.5 µg/kg, respectively)

Formal name: 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, monohydrochloride

Synonyms: 

Molecular weight: 648.2

CAS: 132866-11-6

Purity: ≥98%

Formulation: A solid

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