An inhibitor of nuclear transport; blocks CRM1 interaction with nuclear export signals; inhibits Rev translocation (IC50 = 0.8 nM after 7 hours); antifungal agent

Leptomycin A – 500 µg

Brand:
Cayman
CAS:
87081-36-5
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.{15319} Leptomycin A inhibits Rev translocation, though less potently than leptomycin B (Item No. 10004976) with IC50 values of 0.8 and 0.1 nM, respectively after 7 hours.{31689} Rev export to the cytoplasm is required for HIV-1 replication. Leptomycin A was originally identified as an antifungal agent.  

 

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Description

An inhibitor of nuclear transport; blocks CRM1 interaction with nuclear export signals; inhibits Rev translocation (IC50 = 0.8 nM after 7 hours); antifungal agent

Formal name: (2E,6R)-19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-6-hydroxy-3,5S,7S,9R,11,15R,17-heptamethyl-8-oxo-2,10E,12E,16Z,18E-nonadecapentaenoic acid

Synonyms:  NSC 369326

Molecular weight: 526.7

CAS: 87081-36-5

Purity: ≥99%

Formulation: A solution in ethanol

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases

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