An alkaloid that has diverse biological activities; reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction at 15 mg/kg per day; increases hepatic levels of SOD and GSH

Leonurine – 10 mg

Brand:
Cayman
CAS:
24697-74-3
Storage:
-20
UN-No:
Non-Hazardous - /

Leonurine is an alkaloid that has been found in H. leonuri and has diverse biological activities.{43891,43892,43893,43894} It reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction when administered at a dose of 15 mg/kg per day.{43892} Leonurine (200 mg/kg per day) increases hepatic levels of superoxide dismutase (SOD) and glutathione (GSH), reduces serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and inhibits hepatic fibrosis in a diet-induced mouse model of non-alcoholic steatohepatitis (NASH).{43893} It inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 levels in the serum of broiler chicks when administered at a dose of 120 mg/kg.{43894}  

 

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SKU: 26850 - 10 mg Category:

Description

An alkaloid that has diverse biological activities; reduces infarct size and collagen deposition and inhibits apoptosis of cardiomyocytes in a coronary artery ligation-induced rat model of myocardial infarction at 15 mg/kg per day; increases hepatic levels of SOD and GSH, reduces serum ALT and AST levels, and inhibits hepatic fibrosis in a diet-induced mouse model of NASH at 200 mg/kg per day; inhibits LPS-induced increases in TNF-α, IL-1β, and IL-6 levels in the serum of broiler chicks at 120 mg/kg

Formal name: 4-hydroxy-3,5-dimethoxy-benzoic acid, 4-[(aminoiminomethyl)amino]butyl ester

Synonyms:  SCM 198

Molecular weight: 311.3

CAS: 24697-74-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Superoxide Dismutase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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