A depsidone; active against E. faecalis

Leoidin – 5 mg

Brand:
Cayman
CAS:
105350-54-7
Storage:
-20
UN-No:
Non-Hazardous - /

Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.{52316,52317,48817} It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 µg/ml, respectively).{52317} Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 µM). It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 µM, respectively, in CHO cells expressing the human transporters.{48817}  

 

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SKU: 29939 - 5 mg Category:

Description

A depsidone; active against E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 µg/ml, respectively); inhibits PheRS isolated from P. aeruginosa (IC50 = 42 µM); inhibits OATP1B1 and OATP1B3 (Kis = 0.08 and 1.84 µM, respectively, in CHO cells expressing the human transporters)

Formal name: 2,4-dichloro-3,8-dihydroxy-1,6,9-trimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid, methyl ester

Synonyms: 

Molecular weight: 413.2

CAS: 105350-54-7

Purity: ≥95%

Formulation: A solid

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