Description
An inhibitor of VEGFR2 and VEGFR3 (IC50s = 4 and 5.2 nM, respectively); also inhibits VEGFR1, FGFR1, PDGFRα , PDGFRβ and Kit (IC50s = 22, 46, 51, 39, and 100 nM, respectively); reduces tumor growth in an H146 small cell lung cancer mouse xenograft model at 30 mg/kg, twice per day, and induces tumor regression at 100 mg/kg, twice per day
Formal name: 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide
Synonyms: E-7080|ER-203492-00
Molecular weight: 426.9
CAS: 417716-92-8
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling
