An inhibitor of EphB3 (IC50 = 79 nM)

LDN-211904 – 1 mg

Brand:
Cayman
CAS:
1198408-78-4
Storage:
-20
UN-No:
Non-Hazardous - /

LDN-211904 is an inhibitor of erythropoietin-producing hepatocellular carcinoma (Eph) receptors. In particular, it inhibits EphB3 (IC50 = 79 nM), a tyrosine kinase receptor (RTK) subtype expressed during embryonic development and following central nervous system damage and some cancer cell growth.{32145} At 5 µM, this compound was profiled for inhibitory activity against a panel of 288 kinases and found to inhibit most of the EphA and EphB receptor kinase subtypes except for EphA6 and EphA7, and is non-inhibitory towards the non-RTKs screened except for p38α, p38β, and Qik.{32145}  

 

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Description

An inhibitor of EphB3 (IC50 = 79 nM), an RTK subtype expressed during embryonic development and following central nervous system damage and some cancer cell growth

Formal name: N-(2-chlorophenyl)-6-(4-piperidinyl)-imidazo[1,2-a]pyridine-3-carboxamide, monoethanedioate

Synonyms: 

Molecular weight: 444.9

CAS: 1198408-78-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling

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