A CDK7 inhibitor (IC50 = 50s = >10

LDC-4297 – 1 mg

Brand:
Cayman
CAS:
1453834-21-3
Storage:
-20
UN-No:
De Minimis - 3077 / 9

LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = 50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM).{43200} LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).  

 

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SKU: 23398 - 1 mg Category:

Description

A CDK7 inhibitor (IC50 = 50s = >10, >10, and 1.71 μM); inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively); induces apoptosis in A549, HeLa, and HCT116 cancer cells from 10-100 nM; inhibits HCMV replication in human fibroblasts (EC50 = 24.5 nM); reduces replication of various viruses (EC50s = 0.02-1.13 μM)

Formal name: 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-pyrazolo[1,5-a]-1,3,5-triazin-4-amine

Synonyms: 

Molecular weight: 432.5

CAS: 1453834-21-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Kinase Inhibitors|CDKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HSV

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